Search results for "Evaluation studies"

showing 10 items of 112 documents

Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies

2020

Alpha-lipoic acid (ALA) is a natural short-chain fatty acid that has attracted great attention in recent years as an antioxidant molecule. However, some concerns have been recently raised regarding its safety profile. To address the issue, we aimed to assess ALA safety profile through a systematic review of the literature and a meta-analysis of the available randomized placebo-controlled clinical studies. The literature search included EMBASE, PubMed Medline, SCOPUS, Google Scholar, and ISI Web of Science by Clarivate databases up to 15th August 2020. Data were pooled from 71 clinical studies, comprising 155 treatment arms, which included 4749 subjects with 2558 subjects treated with ALA an…

:Chemicals and Drugs::Pharmaceutical Preparations::Placebos [Medical Subject Headings]Physiologyα -lipoic acid ; thioctic acid ; dietary supplement ; safety ; meta-analysisClinical BiochemistryDisease030204 cardiovascular system & hematologyBiochemistrymeta-analysi:Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants [Medical Subject Headings]Dietary supplementchemistry.chemical_compound0302 clinical medicinethioctic aciddietary supplement meta-analysis safety thioctic acid α-lipoic acid:Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topic [Medical Subject Headings]α-lipoic acidLipoic acidSafety profile:Publication Type::Study Characteristics::Meta-Analysis [Medical Subject Headings]Suplementos dietéticosMeta-analysis:Technology and Food and Beverages::Food and Beverages::Food::Dietary Supplements [Medical Subject Headings]SafetysafetyAlpha-lipoic acidmedicine.medical_specialtyMEDLINEÁcido tióctico030209 endocrinology & metabolismPlacebo:Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Thiophenes::Thioctic Acid [Medical Subject Headings]Article:Health Care::Environment and Public Health::Public Health::Accidents::Accident Prevention::Safety [Medical Subject Headings]03 medical and health sciencesα‐lipoic acidThioctic acidInternal medicineDiabetes mellitusmedicineMetaanálisisAdverse effectSeguridad:Diseases::Cardiovascular Diseases [Medical Subject Headings]Molecular Biology:Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Volatile [Medical Subject Headings]business.industryRevisión sistemáticalcsh:RM1-950Cell Biologymedicine.disease:Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Habits::Food Habits::Smoking [Medical Subject Headings]meta-analysisMeta-analysislcsh:Therapeutics. Pharmacologychemistry:Diseases::Nervous System Diseases [Medical Subject Headings]dietary supplementMeta‐analysisbusinessAntioxidants
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Biological parameters in breast cancer.

1996

AdultAged 80 and overCA15-3Oncologymedicine.medical_specialtyPloidiesbusiness.industryGeneral NeuroscienceBreast NeoplasmsDNA NeoplasmMiddle AgedPrognosismedicine.diseaseGeneral Biochemistry Genetics and Molecular BiologyS PhaseBreast cancerHistory and Philosophy of ScienceEvaluation Studies as TopicInternal medicinemedicineHumansFemalebusinessAged
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Focal nodular hyperplasia: a weight-based, intraindividual comparison of gadobenate dimeglumine and gadoxetate disodium-enhanced MRI

2019

PURPOSE: We aimed to qualitatively and quantitatively compare the enhancement pattern of focal nodular hyperplasia after gadobenate dimeglumine and gadoxetate disodium injection in the same patient. METHODS: 1.5 T magnetic resonance imaging (MRI) examinations of 16 patients with 21 focal nodular hyperplasias studied after the injection of both contrast media were evaluated. Both MRI studies were performed in all patients. A qualitative analysis was performed evaluating each lesion in all phases. For quantitative analysis we calculated signal intensity ratio, lesion-to-liver contrast ratio and liver parenchyma signal intensity gain on hepatobiliary phase. Statistical analysis was performed w…

AdultGadolinium DTPAMaleContrast MediaLiver MRI neoplasm030218 nuclear medicine & medical imagingGadoxetate DisodiumLesion03 medical and health sciences0302 clinical medicineMcNemar's testMegluminemedicineOrganometallic CompoundsHumansRadiology Nuclear Medicine and imagingIntraindividual comparisonAbdominal ImagingGADOBENATE DIMEGLUMINERetrospective Studiesmedicine.diagnostic_testbusiness.industryLiver NeoplasmsFocal nodular hyperplasiaMagnetic resonance imagingMiddle Agedmedicine.diseaseImage EnhancementMagnetic Resonance ImagingLiverEvaluation Studies as TopicFocal Nodular HyperplasiaFemalemedicine.symptomCardiology and Cardiovascular MedicinebusinessNuclear medicineSettore MED/36 - Diagnostica Per Immagini E RadioterapiaWeight based dosing
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Congenital Müllerian anomalies: diagnostic accuracy of three-dimensional ultrasound

1996

Objective To determine whether it is possible to identify and diagnose accurately Mullerian anomalies with three-dimensional (3-D) ultrasound (US). Design Controlled blinded clinical study. Setting Normal human volunteers undergoing infertility evaluation in a university hospital. Patients Forty-two patients who underwent laparoscopy and hysterosalpingography as part of their work up for infertility and were found to have either a normal uterus (30 patients) or a Mullerian abnormality (12 patients) consented to be evaluated with 3-D US by sonographers who were unaware of their infertility history or of their laparoscopy and hysterosalpingography diagnoses. Interventions Transvaginal 3-D US …

AdultGynecologyInfertilitymedicine.medical_specialtymedicine.diagnostic_testArcuate uterusbusiness.industryUltrasoundObstetrics and Gynecologymedicine.diseaseWork-upReproductive MedicineEvaluation Studies as TopicImage Processing Computer-AssistedmedicineEtiologyAnimalsHumansHysterosalpingographyRadiologyAbnormalityLaparoscopybusinessMullerian DuctsUltrasonographyFertility and Sterility
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Complement fixation test in the study of Australia antigen

1971

1810 serum samples obtained from 315 patients with various liver diseases, 44 with miscellaneous non-hepatic diseases and 1133 healthy subjects were assayed for Australia antigen by complement fixation (CF) and immunodiffusion (ID) tests.

AdultLiver CirrhosisMaleHepatitis B virusImmunodiffusionmedicine.medical_specialtyCirrhosisAdolescentCross ReactionsBiologyHepatitisHepatitis B AntigensMedical microbiologyAntigenAntibody SpecificityVirologymedicineHumansHepatovirusChildAgedHepatitisImmune SeraLiver DiseasesComplement Fixation TestsHealthy subjectsAlanine TransaminaseGeneral MedicineHepatitis AMiddle Agedmedicine.diseaseComplement fixation testVirologyImmunodiffusionEvaluation Studies as TopicChild PreschoolAcute DiseaseChronic DiseaseImmunologyFemaleViral hepatitisArchiv f�r die gesamte Virusforschung
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Goldmann Applanation Tonometry Using Sterile Disposable Silicone Tonometer Shields

1996

Abstract Purpose: Placement of a sterile single-use cover over the tonometer tip may be a convenient and safe alternative method to repeated chemical disinfection. This study was undertaken to evaluate the accuracy and performance of Goldmann applanation tonometry using a sterile disposable silicone tonometer shield over the biprism tip. Methods: The same investigator measured intraocular pressure in 120 eyes with and without the shield. The eyes were tested randomly first with either the uncovered or the covered tonometer to control for the possible effects of repeated tonometry influencing measurement differences. Readings were recorded independently in a masked fashion. Results: The intr…

AdultMaleApplanation tonometryIntraocular pressuremedicine.medical_specialtyAdolescentgenetic structuresSiliconesOcular hypertensionGlaucomaSensitivity and SpecificityGoldmann applanation tonometryChemical disinfectionTonometry Ocularchemistry.chemical_compoundSiliconeDouble-Blind MethodOphthalmologymedicineHumansChildDisposable EquipmentIntraocular PressureAgedAged 80 and overAlternative methodsbusiness.industryReproducibility of ResultsGlaucomaMiddle Agedmedicine.diseaseeye diseasesSurgeryOphthalmologychemistryEvaluation Studies as TopicInfertilityFemaleOcular Hypertensionsense organsbusinessOphthalmology
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Evaluation of DNA ploidy and degree of DNA abnormality in benign and malignant melanocytic lesions of the skin using video imaging.

2000

BACKGROUND Making a morphologic distinction between benign and malignant melanocytic tumors of the skin is frequently difficult, especially because “gray zones” between these lesions often exist. DNA image cytometry as an adjuvant method for the diagnosis and prognostic prediction of premalignant lesions and malignant tumors of many other organs is already well established. The aim of this study was to determine whether DNA image cytometry is helpful in distinguishing benign from malignant melanocytic lesions and whether cytometry would give valid information with which to predict the prognoses associated with malignant melanomas. METHODS DNA image cytometry was performed on 127 benign and …

AdultMaleCancer ResearchPathologymedicine.medical_specialtySkin NeoplasmsStatistics as TopicVideo RecordingMalignant transformationBreslow ThicknessHutchinson's Melanotic FreckleNevus BlueNevus Epithelioid and Spindle CellmedicineHumansMelanomaNevusDNA Image CytometryImage CytometryRetrospective StudiesPloidiesbusiness.industryMelanomaCancerReproducibility of ResultsDNA NeoplasmMiddle Agedmedicine.diseaseAneuploidyPrognosisDiploidyHMB-45OncologyEvaluation Studies as TopicImage CytometryMelanocytesFemalebusinessCytometryDysplastic Nevus SyndromePrecancerous ConditionsFollow-Up StudiesForecastingCancer
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Final report of the efficacy and safety of gemtuzumab ozogamicin (Mylotarg) in patients with CD33-positive acute myeloid leukemia in first recurrence

2005

BACKGROUND In this study, the authors analyzed the efficacy and safety of gemtuzumab ozogamicin (GO) (Mylotarg®), an antibody-targeted chemotherapy for CD33-positive acute myeloid leukemia (AML). METHODS Patients with CD33-positive AML in first recurrence were entered in 3 open-label, single-arm, Phase II studies. Patients received monotherapy with GO 9 mg/m2 as a 2-hour intravenous infusion in 2 doses separated by 2 weeks. Patients were evaluated for remission, survival, and treatment-emergent adverse events. RESULTS Two hundred seventy-seven patients (median age, 61 yrs) were treated with GO, and 71 patients (26%) achieved remission, which was defined as ≤ 5% blasts in the bone marrow wit…

AdultMaleCancer Researchmedicine.medical_specialtyMyeloidMaximum Tolerated DoseGemtuzumab ozogamicinmedicine.medical_treatmentCD33Sialic Acid Binding Ig-like Lectin 3Antigens Differentiation MyelomonocyticHematopoietic stem cell transplantationNeutropeniaAntibodies Monoclonal HumanizedGastroenterologyRisk AssessmentSeverity of Illness IndexDrug Administration ScheduleClinical Trials Phase II as TopicAntigens CDRecurrenceInternal medicinemedicineHumansSingle-Blind MethodSurvival rateAgedAged 80 and overChemotherapyDose-Response Relationship Drugbusiness.industryAntibodies MonoclonalMiddle Agedmedicine.diseaseGemtuzumabSurgerySurvival RateLeukemiaLeukemia Myeloid Acutemedicine.anatomical_structureAminoglycosidesTreatment OutcomeOncologyEvaluation Studies as TopicFemalebusinessmedicine.drugFollow-Up StudiesCancer
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Clinical application of a new rheolytic thrombectomy catheter system for massive pulmonary embolism

1999

AdultMaleCardiac Catheterizationmedicine.medical_specialtyPulmonary ArterymedicineHumansRadiology Nuclear Medicine and imagingIntensive care medicineAgedThrombectomybusiness.industryCoronary ThrombosisHemodynamicsGeneral MedicineMiddle Agedmedicine.diseasePulmonary embolismRadiographyCatheterEmbolismEvaluation Studies as TopicFemaleRadiologyPulmonary EmbolismRheologyCardiology and Cardiovascular MedicinebusinessCatheterization and Cardiovascular Interventions
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A German Validation Study of the Inventory to Diagnose Depression

1989

The Inventory to Diagnose Depression (IDD), a self-rating scale designed to identify major depressive episodes (MDE) according to DSM-III, was validated in a sample of 83 inpatients. Depending whether the time criterion of MDE was included or omitted, 63 or 77 patients obtained a syndrome diagnosis of MDE established by means of a structured clinical interview (Polydiagnostic Interview) which served as yardstick. Sensitivity (84.1% with time criterion, 89.6% without time criterion), specificity (60%, 50%), predictive value (67.8%, 64.2%) and kappa (0.43, 0.29) were calculated and found to necessitate improvement for a reasonable application of the IDD in epidemiological and clinical setting…

AdultMaleDepressive DisorderPsychological TestsSelf-Assessmentmedicine.medical_specialtyValidation studylanguage.human_languageGermanPsychiatry and Mental healthClinical PsychologyEvaluation Studies as TopicInterview PsychologicalmedicinelanguageHumansFemalePsychiatryPsychologyDepression (differential diagnoses)Clinical psychologyPsychopathology
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